With an internal transcribed spacer of 18 S, 5.8 S and 26 S nuclear ribosomal DNA (nrDNA ITS) as DNA marker, we report a colorimetric approach for authentication of Pseudostellaria heterophylla (PH) and its copyright species based lycogel on the differentiation of the nrDNA ITS sequence.The assay possesses an unlabelled G-quadruplex DNAzyme molecul
The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study.
Locked nucleic acid (LNA) oligonucleotides bind DNA target sequences forming Watson-Crick and Hoogsteen base pairs, and are therefore of interest for medical applications.To be biologically active, such an oligonucleotide has to efficiently bind the target sequence.Here we used molecular dynamics simulations and electrophoresis mobility shift assay
ATXN3 promotes prostate cancer progression by stabilizing YAP
Abstract Background Prostate cancer (PC) is the most common neoplasm and is the second leading cause of cancer-related deaths in men worldwide.The Hippo tumor suppressor pathway is highly conserved in mammals and plays an important role in carcinogenesis.YAP is one of major key effectors of the Hippo redken shades 9gi pathway.However, the mechanism
Estudo de flebotomíneos (Diptera, Psychodidae) em área urbana do município de Bonito, Mato Grosso do Sul, Brasil Study of phlebotomines (Diptera, Psychodidae) in the urban area of Bonito municipality, Mato Grosso do Sul, Brazil
O objetivo do trabalho foi identificar a fauna flebotomínea em áreas do perímetro urbano do município de Bonito, Mato Grosso do Sul, Brasil.O estudo foi desenvolvido de março de 2005 a fevereiro de 2006, em 17 ecótopos distribuídos em 12 locais, três no Centro e nove em diferentes bairros.As capturas foram realizadas quinzenalmente com arma